Nelson: YES to BRCA test. 18% have germline mutations, even if no FH. Somatic muts also common. BRCA1/2 prognostic& predictive. +association w. other Ca’s. High PPV. Identify ♂️and♀️at risk of Ca. Clinical trial enrollment, esp. PARPi. Stratify for Pl chemo. #EAU18
Nelson: YES to BRCA test. 18% have germline mutations, even if no FH. Somatic muts also common. BRCA1/2 prognostic& predictive. +association w. other Ca’s. High PPV. Identify ♂️and♀️at risk of Ca. Clinical trial enrollment, esp. PARPi. Stratify for Pl chemo. #EAU18